Our work has demonstrated that the people we support are at high risk of multiple morbidity and that their journey through the health system can be hard to navigate. We work with the person not the pathogen to address the underlying determinants of disease and improve health outcomes. Our research has demonstrated that the people we screen and support have a very high burden of TB infection that can be treated to prevent active disease and co-infection with Hepatitis C, B and HIV. We are currently working with Public Health England, the Inclusion Health Board and the Faculty of Homeless and Inclusion Health to design a better outreach service around the needs of the people we serve. This will include expanding our work outside London, incorporating screening for other important infections using point of care tests and ensuring that people are vaccinated and protected.